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SolutionsYield Optimization

Follow a change in yield back to the process.

For MSAT and process engineering teams

A lower titer or recovery figure is the start of a question. Katalyze connects the process and material history so scientists can investigate what changed and choose improvements to evaluate.

Where the time goes

Getting the evidence together takes time.

Records sit across functions, systems, and partners. Experts have to find the relevant details and reconcile them before they can assess the question.

How Agentic Solutions work
Today
With Katalyze
  • Assembling the batch history
  • Defining a useful comparison
  • Connecting results to conditions
  • Choosing an improvement to evaluate
How it works

From the first question to work your team can use.

Katalyze connects evidence, investigates the question, and drafts documents and action plans. Your experts guide the work and decide what follows.

Explore Document Intelligence
  1. 01

    Establish the context

    Connect the relevant recipes, process records, material lots, and performance data for the process and question in scope.

    • Harvest resultsBR-0410 to BR-0421Snowflake
    • Feeding recordsBR-0412 · BR-0415 · BR-0421Document Intelligence
    • P-14 master batch record, Rev 3Veeva Vault
    • Lots 2231-A2231-BSAP
    • Material attributes and process performanceScienceDirect
  2. 02

    Investigate variability

    Test possible explanations against the available batch evidence and identify where further information is needed.

    1. H1Feed timinglater in both lower batches · investigate
    2. H2Feed lot 2231-BBR-0415 comparable · compare
    3. H3Inoculum conditionseed-train records · review
  3. 03

    Prepare the assessment

    Draft an evidence-backed assessment and proposed next steps, so scientists can review the findings and choose what to test.

    Draft 1
    1. 01Twelve batches, feed lot and feed timing beside each
    2. 02Two lower, one same-lot comparison
    3. 03Proposed next comparison · feed execution and material history
    every line cited · for review
Review the evidence

See what supports the finding.

Inspect the supporting records, challenge the interpretation, and see where information is missing. Your experts retain review and approval.

Explore GxP support
Harvest titer across selected batches · draft 1In review
  1. 01Twelve batches, feed lot and feed timing beside each
    Harvest titer · BR-0412 and BR-0421

    The two lower-titer batches show that lot 2231-B lowers harvest titer.

    BR-0412 and BR-0421 have lower harvest titer in this comparison. Both used feed lot 2231-B and recorded a feed addition later than planned. BR-0415 used the same lot without the same decrease. Compare feed timing and material history before drawing a conclusion about cause.

    BR-0415 used the same lot. Compare feed timing before naming the lot.J. M. · MSAT lead
  2. 02Two lower, one same-lot comparison
  3. 03Proposed next comparison · draft 1
Revisedrecorded, with its owner · 4 actions · 1 revision · 1 comment
Feed addition · as planned
  1. PageBatch record BR-0415 · Feeding record
  2. SourceDocument Intelligence · batch records, read from the page
Customer experience

An MSAT team's view of yield and investigations.

Higher yield
Up to 8%
Plant throughput
Up 25%
Increased productivity
30%

Katalyze has shortened the time required to provide insights that would have taken very long to arrive at or even conceptualize altogether. For example, the Katalyze raw material characterization enabled me to identify not just the lot changes aligned with a shift in yield trends but also the attributes of that raw material that changed from the previous lot. This granular information is essential for me as an expert.

Andrew CMSAT Process Lead - Tetanus USP
Questions

Questions about Yield Optimization.

What the work draws on, what your team receives, and how experts use it.

More questions and answers
Book a demo

Start with the question holding work up.

Bring the job you want to move forward and the records you'd like connected. Thirty minutes on how Katalyze would do the work, and where your experts come in.

Or, just a quick chat to run through the product, your call.